Be safe

No danger of uterine hyperstimulation or fetal heart rate changes with Dilapan-S®


Dilapan-S, uterine hyperstimulation

A study group of 185 women, undergoing induction of labor with Dilapan-S® (N=90) or PGE2 (N=95) showed us no risk of uterine hyperstimulation and no impact on the fetal heart change in Dilapan-S® group, compared to the other group, where both of these complications occured.

* Chua, S. et al.: Preinduction Cervical Ripening: Prostaglandine E2 Gel vs Hygroscopic Mechanical Dilator, J. Obstet. Gynaecol. Res., Vol 23, No 2, 1997, 171–177

The use of Dilapan-S® is very safe and does not lead to uterine hyperstimulation or abnormal fetal heart rate

Gentle ripening phase with Dilapan-S®

„The principle role of the agents used for cervical ripening is to soften an unripe cervix independent on uterine activity“ *


Dilapan-S, Graph- % of patients

Onset of the regular uterine activity as a result of pre-induction is negative and unwanted side effect. In a study group of 416 patients, using Dilapan-S® (N=214) and PGE2 (N=202), we can see that in Dilapan-S® , the percentage of patients with mild uterine contractions is significantly lower than in the other group.

* Ramos, L. S. et al.: Induction of Labor, Obstetrics and Gynecology Clinics of North America, 32 (2005), p. 181–200

** Krammer, J. et al.: Pre-induction cervical ripening: A randomised comparison of two methods, Obstetrics and Gynecology, Vol 85, No 4, April 1995, p. 614–618

Dilapan-S® produces minimal uterine activity during the ripening process


Dilapan–S® (N = 196)

Table, during cervical ripening interval

Gupta, J. et al., Synthetic osmotic dilators in the induction of labour—An international multicentre observational study, EJOG, 2019

  • Infectious complications of mother or baby related to usage of dilators:                                0%
  • Suspected fetal pathology based on CTG:     0.2%
  • Apgar score (5 min) < 7:                                    0.7%

Low occurence of adverse events confirms Dilapan-S® favorable safety profile

Ikona, dilepan-S

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