Explore an opportunity

to decrease staff workload, ensure requested efficacy, improve safety and maternal satisfaction with labour induction.

What your colleagues say:

“Adoption of DILAPAN-S is likely to be cost-neutral to dinoprostone vaginal insert, therefore adding this ripening agent to UK practice is not expected to increase hospital spending.”

“DILAPAN-S would be a benefit in women with reduced fetal reserve (IUGR or reduced fetal movement), as it is associated with a lower risk of uterine hyperstimulation.”

“Our trial reaffirms the better maternal satisfaction and safety profile with DILAPAN-S compared with dinoprostone, with similar overall vaginal delivery rates.”

“Outpatient cervical ripening with DILAPAN-S significantly reduced hospital stay.”

“The advantages of DILAPAN-S over Foley balloon include FDA approval, no protrusion from the introitus, no need to keep under tension and improved patient satisfaction.”

Reducing load on maternity units

Minimal complications during cervical ripening

Non-pharma mode of action brings predictability to cervical ripening and allows efficient scheduling on the labour ward

Regular CTG monitoring not required

Midwifes insertion possible

Reduction is staff time requirement by 2.4 hours vs dinoprostone

Reducing load on maternity units

A cost-consequence analysis predicts a reduction in the birth-related staff burden, which could potentially aid in freeing up staff capacity during periods of high demand.

This was primarily due to reduced monitoring requirements when using DILAPAN-S. Moreover, DILAPAN-S was associated with a lower rate of hyperstimulation and need for strong opioid analgesics, which further decreases staff time.

Efficacy

DILAPAN-S achieves reliable first round cervical ripening success

DILAPAN-S achieves reliable first round cervical ripening success

In two clinical trials of over 500 women induced by DILAPAN-S, approximately 4 out of 5 women were ripe successfully with first round of DILAPAN-S series.

In SOLVE trial the rate was approximately by 10% higher than with dinoprostone vaginal insert.

Vaginal delivery rate comparable to prostaglandins

Vaginal delivery rate comparable to prostaglandins

In five clinical trials with in total 1312 women induced by DILAPAN-S, vaginal delivery rate ranged from 63% to 81%, depending on proportion of nulliparous women and clinical protocol used.

When compared with prostaglandins, DILAPAN-S achieved similar vaginal delivery rate, while offering better safety profile and superior maternal satisfaction.

Vaginal delivery date within 24 hours comparable to low-dose oral misoprostol

Vaginal delivery date within 24 hours comparable to low-dose oral misoprostol

DILAPAN-S may offer similar “speed of action” to complete vaginal birth as low- dose oral misoprostol. The outcome predicts that “speed of action“ is related to IOL clinical protocol rather than to the method of cervical ripening.

Reducing load on maternity units

The use of DILAPAN-S ensures comparable efficacy to pharmacological methods while may reduce staff time requirement.

Safety

DILAPAN-S minimizes the risk of uterine tachysystole during cervical ripening

Complications during cervical ripening
Frequency of uterine tachysystole with non-reassuring FHR*

No serious adverse maternal and neonatal outcomes

Dilapan-S
Vaginal bleeding* 3.1 %
Rupture of membranes* 0.9 %
Tachysystole* 0%
Non-reassuring fetal status* 0.5 %
5 min Apgar < 7 0.5 %
Maternal infectious co-morbidity** 0%

RCT DILAFOL, Saad 2019

* During cervical ripening interval
** Related to device used

Non-pharmacological cervical ripening with DILAPAN-S will help you to solve an issue of frequent uterine tachysytole and minimize risk of hyperstimulation with FHR* changes.
NICE guideline encourages discussion with women regarding risks and benefits of each method, incl. safety benefits and risks of mechanical vs pharmacological methods.

Decrease need of analgesics

Decrease need of analgetics

Significantly less women needed analgesia during cervical ripening process in DILAPAN S group , strong opioids analgetics in particular.

Adoption of DILAPAN S can help to improve clinical outcomes, incl . reduction of using analgesia during the process of labour induction.

Maternal satisfaction

Across clinical trials comparing DILAPAN-S with dinoprostone, misoprostol and Foley catheter, more women in the DILAPAN-S group reported:

Better satisfaction as they were able to perform their daily activities

Less frequent and less intense uterine contractions

Lower pain scores during both insertion and cervical ripening

Maternal satisfaction Dilapan-S Dinoprostone
How much pain did you have while the drug/
device was being put in place?
Wong Baker Pain Scale
(0-10 points)
Mean 4.3 Mean 4.7
Mean 4 Median 4
Were you able to perform daily activities such as
walking, dressing, hygiene, shower?
Always 155 (76.0%) 104 (46.9%)
Were you able to get some relaxing time? Always 108 (52.9%) 62 (27.9%)
Were you able to get some sleeping time? Always 97 (48.0%) 49 (22.1%)
Were contractions frequent? Not at All 73 (37.1%) 28 (12.7%)
Were contractions intense? Not at All 87 (44.2%) 34 (15.5%)
Did you feel any discomfort with the drug/ device
in place?
Not at All 92 (46.2%) 59 (22.7%)
Please rate the overall pain that you had while the
drug/device was in place.
Wong Baker Pain Scale
(0-10 points)
Mean 3.1 Mean 5.6
Median 3 Median 6

RCT SOLVE, Gupta 2022

NICE IOL guideline emphasizes “maternal choice” as crucial part of decision making process and call Healthcare Professionals to discuss methods for induction of labour with expectant mothers.

Versatility

Consistent Bishop score gain across all types of induced women

+3.6

All Women

+3.7

Nulliparous

+3.5

Multiparous

+3.8

TOLAC

Solution for out-patient ripening procedure

Recently completed randomised trial confirmed that out-patient use of DILAPAN-S is effective and safe

DILAPAN-S out-patient use shortens significantly stay in hospital, increases vaginal delivery rate within 24 hours after admission and further improves maternal satisfaction with procedure

NICE IOL guideline recommends DILAPAN-S for cervical ripening in the outpatient setting

Several clinical trials evaluated DILAPAN-S as effective and safe in labour induction of women with previous caesarean section.

DILAPAN-S is contraindicated in presence of clinically apparent genital tract infection.

Efficient and gentle cervical ripening suitable for almost all induced women.

DILAPAN-S Training Video

DILAPAN-S in numbers

years of experience on the market
24

years of experience on the market

41 countries we work in
25

countries we work in

95% of women considering insertion of DILAPAN-S® as fully acceptable
80%

of vaginal deliveries

80% of vaginal deliveries
p < 0.003

Consistently superior maternal satisfaction accross multiple clinical trials

Brochure for clinicians

Non-pharma cervical ripening with DILAPAN-S is perfectly suited for outpatient regimen as it does not encourage contractions and contains no pharmacological agents.

Any further information required?

We will get you in touch with your local distributor, so you can try the product yourself.